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CMT-Level-II CMT Level II

Title: CMT-Association CMT-Level-II CMT Level II

Test Detail:
The CMT-Association CMT-Level-II exam, also known as the Chartered Market Technician Level II exam, is a comprehensive assessment of an individual's knowledge and skills in technical analysis and market forecasting. This certification is designed for professionals working in the field of financial markets and investment analysis.

Course Outline:
The CMT-Level-II course provides participants with a deep understanding of advanced technical analysis concepts and their application in financial markets. The following is a general outline of the key areas covered in the certification program:

1. Market Analysis and Theory:
- Understanding market structure and the role of supply and demand.
- Exploring different market trends and phases.
- Applying Dow Theory and other market theories.

2. Elliott Wave Theory:
- Understanding the principles of Elliott Wave Theory.
- Identifying wave patterns and their significance.
- Analyzing market cycles and corrective patterns.

3. Fibonacci Analysis:
- Exploring Fibonacci ratios and their application in technical analysis.
- Using Fibonacci retracements and extensions to identify support and resistance levels.
- Applying Fibonacci time zones in market forecasting.

4. Advanced Chart Patterns:
- Recognizing and interpreting advanced chart patterns, such as double tops/bottoms, head and shoulders, triangles, and wedges.
- Understanding the significance of these patterns in trend reversal and continuation.

5. Oscillators and Indicators:
- Using momentum oscillators, such as RSI (Relative Strength Index) and Stochastic Oscillator, to identify overbought and oversold conditions.
- Analyzing volume indicators and their role in confirming price movements.
- Applying moving averages and other trend-following indicators.

6. Market Breadth Analysis:
- Understanding market breadth indicators, such as advance-decline lines and McClellan Oscillator.
- Interpreting market breadth data to gauge market strength or weakness.
- Using breadth analysis to confirm or diverge from price trends.

Exam Objectives:
The CMT-Level-II exam assesses candidates' understanding and application of advanced technical analysis techniques in financial markets. The exam objectives include, but are not limited to:

1. Demonstrating a comprehensive understanding of market analysis and theory.
2. Applying Elliott Wave Theory to identify market cycles and patterns.
3. Utilizing Fibonacci analysis to identify support and resistance levels.
4. Recognizing and interpreting advanced chart patterns.
5. Using oscillators and indicators to assess market momentum and trend strength.
6. Analyzing market breadth indicators to gauge overall market health.

Syllabus:
The CMT-Level-II certification program typically includes comprehensive training provided by the CMT-Association or authorized training partners. The syllabus provides a breakdown of the topics covered throughout the course, including specific learning objectives and milestones. The syllabus may include the following components:

- Introduction to the CMT-Level-II exam overview and certification process
- Market Analysis and Theory
- Elliott Wave Theory
- Fibonacci Analysis
- Advanced Chart Patterns
- Oscillators and Indicators
- Market Breadth Analysis
- Exam Preparation and Practice Tests
- Final CMT-Level-II Certification Exam
CMT Level II
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CMT-Level-II CMT Level II

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Question: 71
Which of the following factors would NOT increase the predictive power of a dark cloud cover pattern?
A . The dark cloud cover occurs in the middle of a trading range
B . During a downtrend, a white real body with shaven head and bottom followed by a black body also with a shaven
head and bottom
C . If the second day of trading opens above a resistance level and then fails
D . Heavy volume on the second day indicates a buying blow o
Answer: A
Question: 72
Which would be the MOST useful aspect of a cycle in studying the relationship between cycles of different lengths?
A . Phase
B . Period
C . Amplitude
D . None of the above
Answer: A
Question: 73
Using the Point-and-Figure method what is the standard method used to portray the volume on the chart?
A . This is to multiply the volume occurring when each box was in operation
B . This is to sum up the volume occurring when each box was in operation
C . This is to divide up the volume occurring by each box was in operation
D . It is, to sum up, the volume that occurs when every box is not in use
Answer: B
Question: 74
What is the measuring objective for a symmetrical triangle formation?
A. A trendline from the top of the pattern parallel to the lower trendline
B. The height of the base of the triangle
C. Both A. and B. are valid techniques
D. Neither A. nor B. is a valid technique
Answer: C
Question: 75
Which of the following asset classes as a leading indicator for the stock market?
A . Bonds
B . Bullion
C . Precious metal
D . Energy
Answer: A
Question: 76
Which of the following would NOT be true in designing a trading system utilizing bands?
A . Buy when prices penetrate the upper band
B . Close out longs when prices reverse and go below the center of the band
C . Close out shorts when prices reverse and go below the center of the band
D . Sell when price breaks below the lower band
Answer: C
Question: 77
Which of the following BEST describes the rule of alternation?
A . Downtrends follow uptrends
B . Complex patterns follow simple patterns
C . Price follows volume
D . Prices alternate in Fibonacci sequences
Answer: B
Question: 78
Which of the following BEST describes equity market performance during the presidential election cycle:
A . Market has its strongest year during first year of presidents term, posts its worst returns during the pre-election
year and slightly negative returns in election years
B . Market has an above average year during first year of presidents term, posts negative returns during the pre-
election year and its strongest returns in election years
C . Market has a below average year during first year of presidents term, posts its strongest returns during the pre-
election year or in the election year
D . Market has a below average year during first year of presidents term, posts its strongest returns in the second year
and reasonably strong returns during the pre-election and election years
Answer: C
Question: 79
Can stock prices be normally distributed and are stock returns normally distributed?
A . No, you can not have negative prices and every number is possible with any normal distribution. Yes, stock returns
are normally distributed
B . Yes, you can not afford negative prices and with any usual distribution, any number is possible. No, stock returns
are normally distributed
C . Yes, you can not afford negative prices and with any usual distribution, any number is possible. Yes, stock returns
are normally distributed
D . No, you can not have negative prices and every number is possible with any normal distribution. No, stock returns
are normally distributed
Answer: A
Question: 80
Allen Johnson, CMT, is working in the Singapore office of German Investment Corporation. From an informal
conversation, Allen learns that the companys most recent annual report contains misappropriated information. No one
at the Singapore office expresses concern, however, because there has been no breach of Singapores law.
Barrett should:
A . do nothing because the branch is outside of German jurisdiction.
B . seek advice from the company counsel to determine appropriate action.
C . do nothing because the branch is outside of Singapores jurisdiction.
D . disassociate himself from the case with a written report to his supervisor.
Answer: B
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CMT-Association Level action - BingNews https://killexams.com/pass4sure/exam-detail/CMT-Level-II Search results CMT-Association Level action - BingNews https://killexams.com/pass4sure/exam-detail/CMT-Level-II https://killexams.com/exam_list/CMT-Association Establishing Bioburden Alert and Action Levels

Note: This article is based on the white paper "Establishing Bioburden Alert and Action Levels" available for download.

Most national and international standards regarding bioburden, sterilization, or environmental testing recommend establishing alert and action levels to demonstrate continued control over a process or product.

ISO 11737-1:2006 provides guidance on establishing bioburden alert and action levels.1 Clauses A.8.5–8.7 give general guidelines for setting environmental or bioburden levels. This guideline does not dictate how to use the data to establish action and alert levels, nor does it provide guidance on how to interpret the data depending on the sterilization modality in use.

The standard for radiation sterilization, ISO 11137-2:2006, assumes that dose audits are being performed quarterly. Clause 10.1 states

A review of environmental and manufacturing controls, together with determinations of bioburden should be conducted in conjunction with sterilization dose audits. If the review indicates lack of control, appropriate action should be taken.

No definition is provided for the phrase “indicates lack of control.” It is clear that some criteria should be established. Most companies comply with this requirement by establishing alert and action levels for bioburden and environmental counts.

There are many factors involved in establishing bioburden alert and action levels in a variety of situations.

Normal Distribution

The 11737-1 document discusses the fact that bioburden data seldom fit into a normal distribution (i.e., a bell-shaped curve). In evaluating bioburden data consider whether it is important that the data fit a standard statistical model (e.g., normal distribution). That the data fit a standard statistical model is less critical than whether the established levels are based on empirical data and whether they provide safety from a sterilization perspective.

One primary reason that bioburden data do not fit a normal distribution is due to bioburden spikes. It is common to obtain most bioburden values near the mean but also to occasionally have a value that is well above the mean (i.e., a bioburden spike). Bioburden spikes are common in the medical device industry, especially with manual assembly.

The other main reason for bioburden data not fitting a normal distribution is because of the frequent occurrence of zero colony forming units (CFUs) results (e.g., <1 CFU per sample). Standard distribution in this case may be zero; thus, use of standard distributions is impossible, and a different approach is required.

Alert and Action Levels

For alerts and actions, some use the term limits rather than levels. The term limit implies that a product has been effected by an excursion above that value. Use of levels does not imply that the product has automatically been impacted and is generally preferred. A search into established documents and standards provides definitions regarding alert and action levels (or limits). 2–5

Alert Level. Indicates when a process might have drifted from normal operating conditions. An investigation may be performed and corrective action may be implemented, but no action is required. It can be assumed that repetitive excursions above the alert level may be addressed as if it were an action level.

Action Level. Indicates that a process has drifted from normal operating conditions. An investigation must be performed and corrective action must be implemented.

Manufacturers are responsible for setting their own internal specifications for bioburden and environmental alert and action levels. Alert and action levels should be used as a means to monitor manufacturing processes and not as stand-alone product acceptance criteria.

Neither alert nor action levels should be based solely on environmental or bioburden counts without considering the method of sterilization and the amount of overkill in the cycle. In setting the levels there should be a balance between demonstrating adequate control over bioburden without frequently triggering the alert and action levels.
Setting levels is not purely a mathematical exercise. It also involves looking at the proposed levels with common sense.

TNTCs, Spreaders, and Spikes

A bioburden or environmental agar plate may have growth covering the entire surface where distinct colonies cannot be enumerated. These are usually called too numerous to count (TNTC) or spreaders. TNTC describes individual colonies that are indistinguishable because of high numbers of colonies on the filter or plate. Spreaders describe one or more colonies that have covered a portion of or the entire filter or plate. Spreading can be caused by particulates, the nature of the microorganisms, or by fluid on the filter or plate.

TNTC results should not be assigned a CFU value. Using an assigned value beyond the countable range, such as 300, would likely result in an underestimation of the bioburden. In review of any bioburden data, a TNTC result likely indicates a bioburden problem and signals an investigation. The investigation may call for additional testing.

Spreaders do not allow for an accurate count. The count should be discarded when gathering historical data to establish bioburden levels. Spreaders generally indicate a problem with the test method.

Occasionally, spikes are observed in bioburden testing. Currently there is no harmonized definition for a bioburden spike. One common definition is an individual value that is greater than or equal to twice the mean.

Spikes or outliers should be investigated. If they are not true values, then either that value or the entire data set should be discarded. If the investigation determines that they are true values, there may be a bioburden problem in the manufacturing or testing process. It is unwise to set alert and action levels while such a problem is present. If possible, the cause of the spike should be identified and corrected. If this is not done, infrequent spikes could eventually become more frequent.

As part of the investigation, determine whether the spike value raises a potential concern regarding the ability of the current sterilization cycle to provide product that is sterile to the desired sterility assurance level (SAL). This evaluation varies depending on the sterilization mode used and on the bioburden counts at the time of the validation (see Table I).

Each product or product family should be evaluated and established independently, based on historical trends.

Initial Levels

When establishing levels for a new product, use initial or temporary levels until enough data are gathered to establish long-term levels.

Initially test the samples more frequently (e.g., weekly or monthly) to establish a baseline. With these baseline data, temporary alert and action levels can be established. Testing on a typical basis (e.g., quarterly) for the remainder of the year will result in sufficient data for determining long-term alert and action levels.

Three initial sets of data representing three batches can provide a good statistical basis for temporary levels. Use of the same mathematical approaches for establishing temporary versus long-term levels is appropriate with the understanding that the temporary levels may be triggered more frequently.

Create a plan for setting long-term alert and action levels. It should cover the transition of temporary to long-term levels and the frequency of reevaluation.

Long-Term Levels

Once sufficient bioburden data have been gathered, long-term alert and action levels should be established. When gathering data, consider the following to ensure that sufficient data representative of the product have been gathered:

Samples should represent the entire lot. If a manufacturing batch is made specific for testing, extra care must be taken to ensure that the testing batch is representative of routine manufacturing. 2

Bioburden data should be gathered over an extended period of time. It is typical to gather data over one year. 2

At least four sets of data should be used. As more data are gathered, the margin of error decreases. For example, one set of 10 samples per quarter of the year (40 data points) generally provides sufficient trending to establish levels.

Employ a validated recovery efficiency for product bioburden levels. A recovery efficiency validation should be performed for each sample product type (e.g., minimum of three samples) and applied to all data points before data evaluation begins. If multiple recovery efficiencies are determined over time, take the mean of all recovery efficiencies and add them to each set of data. Applying the same recovery efficiency to all data provides for less variation when comparing bioburden estimates and is applicable as long as the same extraction method is used for each set of data. In the bioburden standard, derive the correction factor from the recovery efficiency.

Using standard deviations to set levels is a simple and easy approach. A misleading argument against using standard deviations is that microbiological data may not fit a normal distribution. However, the standard deviation is a useful measure of the dispersion of the data, even if data are not normally distributed.

As a larger sample size of bioburden data becomes available, a move toward a normal distribution may not always be seen. Although a larger sample size could result in a normal distribution of microbiological data, the presence of even a single very high value could result in the data not being normally distributed.

Additionally, a larger sample size of bioburden may not necessarily move toward a normal distribution if there is no growth (e.g., 0 CFU observed). In this situation, the sterilization method may be used to establish the alert and action levels. Another option is to use other distributions and their corresponding statistics to establish levels. Although low bioburden data are said to follow a Poisson distribution, in our evaluation of 47 data sets of product with high bioburden, the Poisson distribution was generally not found.

It is not desirable that the alert level be triggered often, as that would be an indication that there is either too much variability in the bioburden results or that the alert level is too low.

It is best to use the bioburden estimate to establish values rather than bioburden averages or maximum values. This would require that a recovery efficiency be validated for each product type to calculate the bioburden estimate. For environmental monitoring, the bioburden average would be used because a recovery efficiency is generally not performed.

 

Table IIa: This table shows bioburden data-monthly monitoring. Three initial sets of data representing three batches can provide a good statistical basis for temporary levels.

 

Table IIb. From a bioburden perspective, a comparison of the first three months (See table IIa) versus the entire year shows the bioburden estimate and bioburden estimate plus standard deviations are similar. This demonstrates that, as the manufacturing process was refined over time, there was not a significant change and the bioburden is similar.  

Initial Evaluation of the Data

Tests are usually performed monthly for the first quarter, then quarterly for the rest of the year. Using bioburden data from the product in question, the mean, standard deviation, and bioburden estimate for each set can be calculated as well as the overall mean, average standard deviation, and average bioburden estimate. The sum of aerobic bacterial and fungal data for each sample could be used in all calculations.

Additional calculations were performed to determine the bioburden estimate plus two and three standard deviations as well as the bioburden estimate times 10 (see Table II, parts a,b, and c).

From a bioburden perspective, a comparison of the first three months versus the entire year might show that the bioburden estimate and bioburden estimate plus standard deviations are similar. This would demonstrate that, as the manufacturing process was refined over time, there was not a significant change and the bioburden is similar.

Using standard deviations to establish the bioburden levels is similar to the “normal distribution approach” in PDA TR13.2 The alert level can be set at two standard deviations above the historical bioburden estimate, and the action level can be set at three standard deviations above the historical bioburden estimate. This approach results in tight alert and action levels, which would be appropriate for bioburden-based methods such as radiation.

For radiation sterilization using VDmax, there is an established bioburden count that should not be exceeded, which is the maximum bioburden count permitted in the sterilization table being used in ISO 11137-2 and ISO 13004.1.1,6 For example, for 25 kGy, the maximum allowable bioburden count is 1000 CFUs. This would be an example of when the term limit might be appropriate.

When establishing levels for overkill-based methods (e.g., EtO), alert and action levels could be based using the bioburden estimate + 3 × standard deviations and bioburden estimate × 10, respectively. A good limit for such products using overkill methods could be when the bioburden approaches or exceeds the titer of the biological indicator. The amount of safety provided in overkill cycles should allow for greater flexibility in the alert and action levels.

Evaluation of Data Normality

The statistical analysis system (SAS) PROC UNIVARIATE was used to evaluate the normality of 47 different data sets (10 samples per data set). The following four different statistical tests were used in these evaluations: Shapiro-Wilk, Kolmogorov-Smirnov, Cramer-von Mises, and Anderson-Darling. Each of these tests did agree reasonably well on the determination of the normality of each of these data sets. Many data sets were found to be abnormal due to a single outlier, which was more than twice the standard deviation beyond the mean (33 out of 47, or 70%).

In the evaluation of these data sets, it was determined whether each data set had a single outlier, which was defined as a single data point more than twice the standard deviation beyond the mean (i.e., mean + 2 standard deviations). Most data sets were either abnormal due to an outlier or normal due to no outlier (39 out of 47 or 83% were deemed abnormal). This result demonstrates that using the SAS program may be a simple and reasonably accurate way to determine whether a given data set has an influential outlier.

When the initial sets of 10 were grouped into sample sizes of 20 or 30 data points (based on product type) and evaluated as described earlier, the data did not become normal solely based on a larger sample size. In fact, the rule of thumb described worked with each of the data sets in determining normality (100%).

Conclusion

There are many factors involved in establishing alert and action levels for product and environmental bioburden. A thorough review of bioburden data can assist in selecting the best approach for the situation. The approaches discussed here have functioned well for a variety of product and sterilization types.

There is often discussion in the industry regarding the appropriateness of standard distributions for evaluating bioburden data. Fitting the bioburden data into a specific statistical distribution is less critical than understanding the ranges of bioburden over time.

An important part of this process is having a good definition for alert and action levels and understanding what should occur when each is triggered. Different sterilization types should require different numerical levels as well as specified follow-up actions.


References

  1. SO 11737-1:2006, “Sterilization of Medical Devices—Microbiological Methods—Part 1: Determination of a Population of Microorganisms on Products” (Geneva: International Organization for Standardization, 2006).
  2. PDA Technical Report 13, “Fundamentals of an Environmental Monitoring Program” (Bethesda, MD: Parenteral Drug Association, 2001).
  3. USP <1116>, “Microbiological Control and Monitoring of Aseptic Processing Environments” (Rockville, MD: United States Pharmacopoeial Convention, 2012)
  4. USP <1231>, “Water for Pharmaceutical Purposes” (Rockville, MD: United States Pharmacopoeial Convention, 2012)
  5. Code of Federal Regulations 21 CFR 211.
  6. ISO 13004, “Sterilization of Healthcare Products— Radiation—Substantiation of Selected Sterilization Dose: Method VDmaxSD” (Geneva: International Organization for Standardization, July 2013 [not yet published]).

Martell Winters is a senior scientist at Nelson Laboratories, where he has worked for 18 years. He has been involved in writing AAMI/ISO and AATB documents for 15 years. Winters is a registered microbiologist and the specialist microbiologist. 
Esther Patch is study director II for Nelson Laboratories. She graduated with a degree in chemistry with an emphasis in biochemistry and a minor in biology from Erskine College and Seminary (Due West, SC). She is a national registered biologist. 
Wendy Wangsgard is bioburden department scientist and has been with Nelson Laboratories for eight years. She is involved with the radiation sterilization, microbiological methods, sterility assurance level, and other working groups of AAMI. 
Harry Bushar is an independent statistician currently employed part-time by FDA. He has served as a member of the AAMI Radiation Sterilization Subcommittee and the Gamma Radiation Sterilization Working Group. 
Ashley Ferry is a quality assurance investigator at Nelson Laboratories. Ferry also audits testing to ensure compliance with cGMPs, ISO/AAMI, USP, and internal SOPs and STPs. She is a registered microbiologist. 

Thu, 30 May 2013 12:00:00 -0500 en text/html https://www.mddionline.com/sterilization/establishing-bioburden-alert-and-action-levels
Gordon Scott

Experience

Gordon Scott has been an active investor and has provided education to individual traders and investors for over 20 years. He is a licensed broker, an active trader, and proprietary day trader.

Gordon teaches the Investopedia Academy's Penny Stock Trading course, but his background in instruction is broad and deep. From 2013 to 2018 he was the Managing Director of the Chartered Market Technician (CMT) designation's examination program for the CMT Association (cmtassociation.org). The CMT is a globally-accepted technical analysis credential in the financial industry.

Gordon has over 15 years experience as a trading coach. For four years, he was the content manager at Investools, which publishes research and commentary on trading strategies. Gordon developed an online curriculum and oversaw its growth during the Thinkorswim and TD Ameritrade mergers.

Gordon's career also includes 10-years with International Business Machines Corporation (IBM), where he developed instructional materials and business process refinement. He also was an Adjunct Instructor at Brigham Young University–Organizational Strategy and Leadership department.

Gordon is co-author of the book, Invest to Win (McGraw-Hill 2013), with Toni Turner. The book provides insight on investing approaches and in managing a bullish portfolio known as the GainsMaster Investing method.

Tue, 07 Nov 2023 01:58:00 -0600 en text/html https://www.investopedia.com/contributors/82594/
Stella Osoba

Experience

Stella Osoba enjoys a distinguished career as a financial, legal, and business writer, a technical analyst, and an independent trader. She produces a wide range of content for print, digital, blog, multimedia, and animation projects. Stella’s work includes articles on behavioral finance, trading, and technical analysis. An attorney, Stella left a career in law to pursue freelance writing, teaching, and lecturing. Her deep experience and knowledge base include the disciplines of transactional analysis, financial report analysis, and business litigation; statistical and technical analysis of price patterns, volume history, and measures of trend, momentum, and volatility; trading, risk management, inter-market analysis, behavioral finance, market history, and ethics.

Stella is active in the CMT Association—a global credentialing body with nearly 15 years of service to the financial industry. She was a co-founder and chair of Women in Technical Analysis, a chapter of the CMT Association, which is designed to increase opportunities for women to network and form meaningful contacts in the finance industry. Stella has worked for Wiley Publishing Company to develop material for their online CMT Test Bank and was a grader for the CMT Level 111 exam. Stella is frequently chosen to lead initiatives that require skill in assessing technical data, and serves as a mentor and teacher to traders and other professionals in financial services.

Education

Stella was admitted as a Barrister-at-Law in England and Wales and is a member of Middle-Temple Inn of Court. She studied law at Warwick University School of Law (London), She is also admitted to the Bars of New York and California. She is a Chartered Market Technician (CMT).

Mon, 16 Nov 2015 05:34:00 -0600 en text/html https://www.investopedia.com/contributors/53997/
'Son of a Sinner' Jelly Roll reigns at CMT Music Awards show

NASHVILLE, Tenn. — “Son of a Sinner” singer Jelly Roll was the big winner at the CMT Music Awards, as the rapper-turned-country singer took home three awards on Sunday as an outsider who won over fans with his confessional songs.

The tattooed singer got emotional during the show in Austin, Texas, which aired on CBS, as he thanked the country radio industry for its acceptance and shouted out to those who felt like him.

“You can be whatever you want to be. I promise you that. I told them that I wanted to be a country singer and I am standing here at the CMT Awards with the male video of the year, baby,” he shouted.

Earlier in the night, he brought a choir out for his prayer-themed song “Need a Favor” and got the crowd to raise their hands to the roof.

The show started off with a somber tone as country singer and co-host Kelsea Ballerini read off the names of six victims of a school shooting killed Monday in Nashville, Tennessee. She noted how she shared their pain, explaining that in 2008 she witnessed a school shooting in her hometown high school cafeteria in Knoxville and prayed for “real action” that would protect children and families. Earlier in the evening, country artists wore black ribbons on the red carpet to honor victims of the shooting.

But the show prioritized nostalgia overall as performances merged rock, blues and country straight from the heart of Texas, mixing in tributes and covers alongside newer artists and fan-favorite hit songs.

Country superstar and five-time Grammy winner Shania Twain was given the Equal Play Award, recognizing her for being a “visible and vocal advocate” for diverse voices in country music. Texas native and Grammy-winning rapper Megan Thee Stallion introduced Twain and the pair danced and hugged to Twain’s hit, “Man, I Feel Like a Woman.”

The lyrics to the song became an undercurrent to a decades-long career of advocacy, Twain said.

“I promise I will continue to champion the many outstanding country artists that are not currently played, they are not currently streamed, toured, signed or awarded at the level they deserve,” Twain said. “I believe in an all-inclusive country music.”

Lainey Wilson won twice with female video of the year for “Heart Like a Truck” and collaborative video of the year for “Wait in the Truck” with HARDY.

“My heart is ‘bout to beat right out my chest, I’ll be honest with y’all,” Wilson said after winning female video of the year, calling the hit song an anthem for surviving the “scratches, the dents and the bumps along the way.”

Co-host Kane Brown took home the last award of the night with his wife, Katelyn, winning video of the year for their duet, “Thank God.”

“This is all so new to me. And when we recorded this song a year ago, I never in my life would ever think this was ever going to happen,” Katelyn Brown said.

Later in the show Ballerini took to the stage flanked by drag artists, as states across the country consider legally limiting drag show performances. The Tennessee native sang “If You Go Down (I’m Going Down Too)” and danced with Kennedy Davenport, Jan Sport, Manila Luzon and Olivia Lux, all stars of the show “RuPaul’s Drag Race.”

Tennessee was the first state to place strict limits on drag show performances, which were set to take effect this month. The law has been temporarily blocked after a lawsuit was filed earlier this week.

Collaborations took center stage for most of the three-hour show. Country Music Hall of Famer Wynonna Judd and Ashley McBryde performed a cover of Foreigner’s “I Want to Know What Love is” while heavy fog rolled over the stage and into the crowd.

Pop singer Stefani performed her No Doubt mid-1990s pop-punk hit “Just a Girl” alongside country singer Carly Pearce. Rocker Alanis Morissette brought more of the ’90s rock to the stage with a group performance of “You Oughta Know” featuring Wilson, Ingrid Andress, Madeline Edwards and Morgan Wade.

Carrie Underwood, the most-awarded artist in CMT history with 25 awards, performed “Hate My Heart” as fireworks lit up the Austin night. Four-time Grammy winner Clark Jr. performed a tribute to the late Texas guitarist Stevie Ray Vaughn at the top of the show.

Southern rockers Lynyrd Skynyrd were honored with a tribute performance following the death in March of the last original member, Gary Rossington. ZZ Top’s Billy Gibbons, Slash of Guns N’ Roses and the Allman Brothers’ Warren Haynes and Chuck Leavell wrapped the show with singers Paul Rodgers and Cody Johnson and backup vocals from LeAnn Rimes and Judd.

Sun, 02 Apr 2023 21:33:00 -0500 en-US text/html https://triblive.com/aande/music/son-of-a-sinner-jelly-roll-reigns-at-cmt-music-awards-show/
September home sales drop to the lowest level since the foreclosure crisis
September home sales drop to the lowest level since the Great Recession

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Sales of previously owned homes dropped 2% in September from August to a seasonally adjusted, annualized rate of 3.96 million units, according to the National Association of Realtors. Sales were 15.4% lower compared with September 2022.

This is the slowest sales pace since October 2010, during the Great Recession, when the market was in the midst of a foreclosure crisis. As a comparison, just two years ago, when mortgage rates hovered around 3%, home sales were running at a 6.6 million pace. The average rate on the 30-year fixed today is right around 8%, according to Mortgage News Daily.

"As has been the case throughout this year, limited inventory and low housing affordability continue to hamper home sales," said Lawrence Yun, NAR's chief economist. "The Federal Reserve simply cannot keep raising interest rates in light of softening inflation and weakening job gains."

There were 1.13 million homes for sale at the end of September, down more than 8% from a year ago. Inventory is now at a 3.4-month supply, which is slightly better than last year, but only because sales have dropped so much. Supply is based on the current sales pace.

Adding to higher mortgage rates, the median price of a home sold in September was $394,300, up 2.8% year over year. Roughly 26% of home sold above list price, due to the lack of supply which is resulting in bidding wars.

First-time buyers made up just 27% of sales. Historically, they make up about 40%.

While sales were lower across all price points, they fell the least on the higher end. That's because there is more supply at the higher price points and because higher-end buyers can often use cash. Mortgage demand is now at the lowest level since 1995, according to the Mortgage Bankers Association.

All-cash sales made up 29% of all September transactions, up from 27% in August and up from 22% in September of last year.

"Although affordability is a headwind, the renewed upward energy that followed the Fed's September projections might have prompted some shoppers to rush to the closing table, lest they face higher mortgage rates and even worse affordability in the months ahead. If so, this could mean a bigger lull in sales activity in the coming months," said Danielle Hale, chief economist for Realtor.com, in a release.

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Clarification: This story has been updated to clarify that sales were 15.4% lower compared with September 2022.

Thu, 19 Oct 2023 02:00:00 -0500 en text/html https://www.cnbc.com/2023/10/19/september-home-sales-drop-to-lowest-level-since-the-foreclosure-crisis.html
The best action movies on Netflix right now

The best action movies on Netflix right now include some all-time classics, at least one major 2023 summer blockbuster, and a whole lot more. But, like with any collection on Netflix, the library is always changing. There are a few quality additions for November, and we’re keeping tabs on them for you to curate this list to help you keep up the action on your next movie night.

We’ve also curated guides to the best action movies on Amazon Prime, the best action movies on Disney+, and the best action movies on Hulu if you’re looking for additional recommendations.

Save on everything from laptops and tablets, to coffee makers and air purifiers, and a whole host of Apple tech like iPad, Apple Watch and even the latest M3 MacBooks, as well as smart home essentials like the Amazon Echo and smart bulbs.

Digital Trends streaming roundup

Editors' Recommendations

Mon, 06 Nov 2023 10:01:00 -0600 en text/html https://www.digitaltrends.com/movies/best-action-movies-on-netflix/
Out of All the Action Comedy Hunks, John Cena Gets the Assignment Most No result found, try new keyword!Back in 2006, when John Cena was just known as a WWE wrestler who was headlining scrappy B-level action movies like The Marine, the idea of him being a poster child for modern action comedy hunks ... Thu, 02 Nov 2023 13:13:00 -0500 en-us text/html https://www.msn.com/ Innovation in action
The University of Delaware's STAR Campus

The University of Delaware’s STAR Campus is an example of innovation-based economic development, where public-private partnership in university-anchored ecosystems can help power the state’s economy, bolster business creation and innovation, and foster workforce-development and student success.

Photos by Kathy F. Atkinson and Dave Levandoski

Norbert Mórucz traveled more than 4,400 miles to attend the 2023 international conference of the Association of University Research Parks in Delaware, Oct. 16-19. Mórucz is president of the Association of Science and Technology Parks in Budapest, Hungary, an association of 20 technology parks and 14 science parks. 

A new AURP member and first-time conference attendee, Mórucz was eager to learn about U.S. models for technology and innovation park development, to network and to make connections with potential American partners. 

“Universities today are not just for education and research, but also for technology development and innovation, and business,” Mórucz said. “We want to set up joint ventures, collaborate and provide a pipeline and soft landing for Europeans to come here, but need advice on how to go about this.”

With over 245 research park leaders and innovation district leaders in attendance, there were plenty of bright minds to tap for ideas at the conference, hosted this year by the University of Delaware and its Science, Technology and Advanced Research (STAR) Campus.

UD President Dennis Assanis welcomed the attendees to Delaware, noting the alignment between the conference theme of innovation powered by people, places and purpose and the culture developing across the STAR Campus.

He pointed out that UD’s STAR Campus is an example of innovation-based economic development, where public-private partnership in university-anchored ecosystems can help power the state’s economy, bolster business creation and innovation, and foster workforce-development and student success. With more than 30 companies on STAR and more than 1 million square feet of modern labs, classrooms, clinical spaces and offices, connected by greenspace, there is a neighborhood feel that encourages creativity, collaborations and community building.

“These kinds of technology and innovation hubs are at the heart of what I think is our modern-day land-grant mission. The ecosystem that grows up around a particular industry — for example, biopharmaceuticals here at STAR Campus — becomes self-perpetuating,” said Assanis, who was appointed by President Biden to the President's Council of Advisors on Science and Technology. “Education spurs research and innovation, which draws entrepreneurs and builds engagement with the community, which increases the need for educated workers in that field, and so on.”

Valuable collision spaces

Brian Darmody, AURP chief strategy officer, is the author of several white papers on the value of research parks. He noted that innovation districts improve the likelihood that student talent remains in an area, instead of being recruited elsewhere after graduation. This happens when students get to experience the robust ecosystem and facilities early on through internships or work experiences, such as those available with STAR Campus partners and tenants. These students then become part of the community, finding jobs, paying taxes, buying homes, growing families and otherwise contributing to the local economy. 

Situating a diversity of businesses, nonprofits and researchers in one space also increases what Darmody calls “bumpability,” the likelihood that a researcher from one discipline could bump into someone working in a different technology area and discover some common ground. 

“UD’s STAR Campus is an example of a well-designed collaboratory, where people can have their own independent space but have lots of reasons to meet with other folks,” Darmody said.

Attendees of the international conference of the Association of University Research Parks

The 2023 international conference of the Association of University Research Parks drew more than 240 research park leaders and innovation district leaders from around the world to UD’s Science Technology and Advanced Research (STAR) campus.

These opportunities and connections provide staying power for area businesses and generate tax revenue for the state, acting as an economic driver.

“When you put nonprofits, academia and private industry together in one ecosystem, innovation and research translation accelerates; student experience, learning and hiring grows,” said Tracy Shickel, associate vice president of corporate engagement at UD and AURP board member.

AURP visitors had the opportunity to tour leading-edge STAR Campus facilities, including NIIMBL — the National Institute for Innovation in Manufacturing Biopharmaceuticals. NIIMBL is a Manufacturing USA network of over 200 members headquartered in the Ammon Pinizzotto Biopharmaceutical Innovation Center and focused on improving biopharmaceuticals manufacturing and educating the future biopharmaceutical workforce. They also visited the FinTech Innovation Hub, the latest gem in UD’s innovation neighborhood, centered on work aimed at improving equity in financial services and health.

A moderated panel discussion on the transformative role of hydrogen in clean energy research provided AURP members an overview of cutting-edge technologies, applications and policies that will power a more sustainable future for society. UD is a trailblazer in this area, collaborating to accelerate technology development through its Center for Clean Hydrogen, launched in 2022, and building the region’s clean energy workforce through its role in the recently announced Mid-Atlantic Clean Hydrogen Hub.

Attendees also learned how corporate-university connections are changing the way JPMorgan Chase hires its technology talent. According to Jennifer McDermott, JPMC executive director of global technology workforce strategy, one out of every three employee roles at JPMC are tech related, amounting to about 55,000-60,000 technologists across the financial services company. These jobs are not only in high demand, but they are also higher-paying jobs.

Proximity to talent and diversity is key to sustaining a strong technology pipeline, she said, as are programs that provide alternative pathways for talent development. UD’s Spectrum Scholars, a college-to-career program designed to break down barriers to access for students with autism collaboratively developed by UD and JPMC, is one such example. 

Gov. John Carney recalled Delaware’s evolution over the last 50 years from a state well-known for a few large employers, such as the DuPont Company and Chrysler, to a small business state with a bustling innovation-based economy. 

“We knew to be successful as a state we had to diversify our economy. We had to get focused on small business and science and technology-based companies, and that’s what we did,” Carney said.

The transformation of UD’s STAR Campus — the site of a former Chrysler automotive plant — is a shining example of this in action. Today, more than 3,000 people work on the STAR Campus, a greater number than when the automotive plant was producing Dodge Durangos more than 20 years ago. 

Delaware State University (DSU), a Historically Black College and University (HBCU) located in Dover, Delaware, is moving in the same direction, working to develop science and technology-based innovation and businesses, and preparing students to be leaders in the workforce of the future.

Tony Allen, president of Delaware State University, speaks at the 2023 international conference of the Association of University Research Parks

Keynote speaker Tony Allen, president of Delaware State University, a UD alumnus and former member of UD’s Board of Trustees, spoke about the wealth of talent in Historically Black Colleges and Universities (HBCUs) and the value they bring to powering an innovation pipeline.

Keynote speaker Tony Allen, president of DSU, spoke about the value of HBCUs in powering this innovation pipeline. HBCUs, Allen said, comprise a mere 3% of universities nationwide, yet these institutions educate 20% of Black graduates. This amounts to nearly 300,000 graduates annually. Allen, who is a UD alumnus, is interested in building capacity for businesses to grow on HBCU campuses and leverage this sometimes-untapped wealth of talent.

“When you think about the ability to change lives across any discipline, think about how important it is to bring diversity of people, experience and ideas into the marketplace,” said Allen, who chairs President Biden’s Board of Advisors on Historically Black Colleges and Universities. “Think about what that will mean for our country and for our smaller, globally connected world and how you can partner with our HBCUs.”

Carney said there are reasons for Delaware’s success. Borrowing a phrase from his predecessor, former Gov. Jack Markell, Carney referred to Delaware as “a state of neighbors,” saying, “I just love that terminology, because we’re very small, barely one million people, and we have this tradition of knowing one another and working together to get things done.” 

Efforts to shore up gaps in Delaware’s innovation ecosystem are an apt example of this. Take UD’s three University-related research campuses, for example: Delaware Technology Park and UD’s STAR Campus in Newark, and the Innovation Space in Wilmington. 

“As companies or startups formed, and technologies were licensed, we had incubation space for them, but as they grew, they often had to move out of the region,” Shickel said. 

Through partnerships with state elected officials, the university and commercial real estate market, those gaps have been filled, so that businesses like Prelude Therapeutics, a clinical-stage biopharmaceuticals company, now have support and space to expand. Prelude Therapeutics started at STAR Campus, grew to the Innovation Space, and now is putting its permanent headquarters at the Chestnut Run Innovation and Science Park (CRISP) campus in Wilmington, Delaware. 

And while the development at STAR Campus has been tremendous over the last decade, Shickel said, with just over 10% of the 272 acres on the STAR campus currently developed, they’ve barely scratched the surface of what’s possible.

“This is a tremendous economic and innovation impact success story,” Shickel said. 

Throughout the remainder of the conference, AURP members had the opportunity to visit a cross-section of other regional innovation ecosystem models with varying funding mechanisms, ownership models, missions, objectives and tenant mixes, including The Mill in Wilmington and the Brandywine Realty Trust in Philadelphia, Pennsylvania.

Wed, 25 Oct 2023 12:00:00 -0500 en text/html https://www.udel.edu/udaily/2023/october/star-campus-association-of-university-research-park-international-conference/
See the Gates in Action

Type of gate: disappearing oscillating buoyancy flap gate

Number of gates: 4 rows at three locations (Lido, 2 rows; Malamocco, 1 row; Chioggia, 1 row)

Number of individual gate sections: 79 (Lido, 41; Malamocco, 20; Chioggia, 18)

Individual gate dimensions: 66 feet wide, 15.5 feet thick, 99 feet long at deepest point

Weight of each gate: 250 - 350 tons

Height of tides when gates operate: 40 inches or more above average

Average lagoon inlet closure time: 4.5 hours

Time necessary to open the gates: 30 minutes

Time necessary to close the gates: 15 minutes

Maximum difference in level between sea and lagoon when gates are raised: 6.6 feet

Cost of the project: $1.9 billion

Project execution time: 8 years

Number of direct jobs during execution: 1,000 per year

Number of direct jobs when fully operational: 150 per year

Maintenance and management costs: $9.2 million per year ($6.2 million for maintenance, $3 million for management)

Tue, 13 Sep 2011 18:09:00 -0500 en text/html https://www.pbs.org/wgbh/nova/venice/gates.html
Regenacy is poised to deliver the first treatment for peripheral neuropathy

Peripheral neuropathy affects nerves outside of the brain and spinal cord. Dysfunction of these nerves can cause spontaneous, inappropriate signals or loss of signals, leading to symptoms such as pain and numbness. This condition affects more than half of all diabetic adults, approximately 500,000 chemotherapy-treated patients, and an estimated one million individuals with an inherited degenerative nerve condition called Charcot–Marie–Tooth disease type 2 (CMT2). Peripheral neuropathy can cause severe disability and increases the risk of limb amputation, which significantly diminishes quality of life, but currently there is no approved treatment. Regenacy Pharmaceuticals is developing a novel, disease-modifying approach to treating peripheral neuropathies that goes beyond pain and symptom management to restore peripheral nerve function. The company’s lead compound ricolinostat is an oral, selective inhibitor of the microtubule-modifying enzyme histone deacetylase 6 (HDAC6). With first-in-class potential, ricolinostat is currently positioned to enter a phase 2 clinical trial for diabetic neuropathic pain.

“Temporary, symptomatic treatments for neuropathic pain are poorly tolerated, minimally effective and addictive,” said Regenacy’s vice president of research and development Matthew Jarpe. “Unlike approved medicines, ricolinostat is well tolerated, non-addictive, and has potential to achieve lasting relief of all neuropathy symptoms rather than transient relief of some symptoms.”

Restoring nerve function

Neurons conducting signals to and from the spinal cord into the feet and hands are the longest cells in the body. These neurons rely on an internal micro-tubule transport network to supply energy and nutrients to maintain nerve ends in the skin and muscles. When this transport is disrupted by disease nerve cells can malfunction and send random signals, resulting in pain, tingling, muscle spasms, or no signal at all, leading to numbness or paralysis. These are the symptoms of peripheral neuropathy that can result from diabetes, chemotherapy, and mutations.

Intracellular transport is regulated by HDAC6—a microtubule-associated deacetylase that plays a significant role in axonal functioning in the nervous system. Inhibition of HDAC6 is a novel approach to restoring nerve function for the treatment of peripheral neuropathies by re-establishing the transport function of microtubules (Fig. 1). Phase 1 and 2 clinical trials in 250 cancer patients’ demonstrated ricolinostat’s excellent safety and tolerability profile, particularly when contrasted with the high toxicity of currently marketed, nonspecific pan-HDAC inhibitors such as vorinostat and panobinostat.

Fig. 1 | Mitochondrial transport by histone deacetylase 6 (HDAC6). HDAC6 is a key regulator of fast axonal transport, which is impaired in distal symmetric polyneuropathy. The slowing of transport in the longest nerves leads to dysfunction of the nerve terminals, causing pain symptoms, numbness and tingling. These appear in a‘stocking and glove’ pattern in patients with diabetes, inherited neuropathy or in patients undergoing chemotherapy.

Moreover, preclinical studies in multiple models of genetic and induced forms of peripheral neuropathy provide compelling evidence that HDAC6 inhibition normalizes the function of damaged peripheral nerves. In animal models of chemotherapy-induced neuropathy, ricolinostat reduces pain and numbness, restores nerve function, promotes nerves to grow back into the skin, and exerts long-lasting effects that persist for days after the end of dosing, suggesting a disease-modifying capability. Similar effects are seen in models of diabetic neuropathy and CMT2. “We plan to explore the efficacy of ricolinostat in diabetic peripheral neuropathy patients first,” Jarpe said. “Later we will expand into chemotherapy induced neuropathy and CMT2.”

Expanding horizons

Currently, Regenacy is seeking additional partnerships to develop its portfolio of HDAC inhibitors.

Recently, the company announced a collaboration with the Charcot–Marie–Tooth Association, a non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of CMT2 and evaluate the efficacy of ricolinostat in animal models to support the initiation of clinical trials.

“We are thrilled to have such a substantial collaboration to broaden our programs for ricolinostat into inherited forms of neuropathy where there is a tremendous unmet need,” Jarpe said. “This and future alliances will position us to deliver a superior, first-in-class treatment for peripheral neuropathies, which affect many millions of people worldwide.”

Thu, 03 Sep 2020 16:21:00 -0500 en text/html https://www.nature.com/articles/d43747-020-00620-4




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